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Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICU

《医学前沿（英文）》 2023年 第17卷 第4期   页码 675-684 doi: 10.1007/s11684-022-0970-x

摘要： This study aimed to explore key quality control factors that affected the prognosis of intensive care unit (ICU) patients in Chinese mainland over six years (2015−2020). The data for this study were from 31 provincial and municipal hospitals (3425 hospital ICUs) and included 2 110 685 ICU patients, for a total of 27 607 376 ICU hospitalization days. We found that 15 initially established quality control indicators were good predictors of patient prognosis, including percentage of ICU patients out of all inpatients (%), percentage of ICU bed occupancy of total inpatient bed occupancy (%), percentage of all ICU inpatients with an APACHE II score ≥15 (%), three-hour (surviving sepsis campaign) SSC bundle compliance (%), six-hour SSC bundle compliance (%), rate of microbe detection before antibiotics (%), percentage of drug deep venous thrombosis (DVT) prophylaxis (%), percentage of unplanned endotracheal extubations (%), percentage of patients reintubated within 48 hours (%), unplanned transfers to the ICU (%), 48-h ICU readmission rate (%), ventilator associated pneumonia (VAP) (per 1000 ventilator days), catheter related blood stream infection (CRBSI) (per 1000 catheter days), catheter-associated urinary tract infections (CAUTI) (per 1000 catheter days), in-hospital mortality (%). When exploratory factor analysis was applied, the 15 indicators were divided into 6 core elements that varied in weight regarding quality evaluation: nosocomial infection management (21.35%), compliance with the Surviving Sepsis Campaign guidelines (17.97%), ICU resources (17.46%), airway management (15.53%), prevention of deep-vein thrombosis (14.07%), and severity of patient condition (13.61%). Based on the different weights of the core elements associated with the 15 indicators, we developed an integrated quality scoring system defined as F score=21.35%×nosocomial infection management + 17.97%×compliance with SSC guidelines + 17.46%×ICU resources + 15.53%×airway management + 14.07%×DVT prevention + 13.61%×severity of patient condition. This evidence-based quality scoring system will help in assessing the key elements of quality management and establish a foundation for further optimization of the quality control indicator system.

关键词： critical care medicine     quality control     evaluation     exploratory factor analysis (EFA) model    

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Solving topology optimization problems by the Guide-Weight method

Xinjun LIU, Zhidong LI, Liping WANG, Jinsong WANG

《机械工程前沿（英文）》 2011年 第6卷 第1期   页码 136-150 doi: 10.1007/s11465-010-0126-6

摘要：

Finding a good solution method for topology optimization problems is always paid attention to by the research field because they are subject to the large number of the design variables and to the complexity that occurs because the objective and constraint functions are usually implicit with respect to design variables. Guide-Weight method, proposed first by Chen in 1980s, was effectively and successfully used in antenna structures’ optimization. This paper makes some improvement to it so that it possesses the characteristics of both the optimality criteria methods and the mathematical programming methods. When the Guide-Weight method is applied into topology optimization, it works very well with unified and simple form, wide availability and fast convergence. The algorithm of the Guide-Weight method and the improvement on it are described; two formulations of topology optimization solved by the Guide-Weight method combining with SIMP method are presented; subsequently, three numerical examples are provided, and comparison of the Guide-Weight method with other methods is made.

关键词： Guide-Weight method     topology optimization     SIMP method    

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Heuristic solution using decision tree model for enhanced XML schema matching of bridge structural calculation documents

Sang I. PARK, Sang-Ho LEE

《结构与土木工程前沿（英文）》 2020年 第14卷 第6期   页码 1403-1417 doi: 10.1007/s11709-020-0666-8

摘要： Research on the quality of data in a structural calculation document (SCD) is lacking, although the SCD of a bridge is used as an essential reference during the entire lifecycle of the facility. XML Schema matching enables qualitative improvement of the stored data. This study aimed to enhance the applicability of XML Schema matching, which improves the speed and quality of information stored in bridge SCDs. First, the authors proposed a method of reducing the computing time for the schema matching of bridge SCDs. The computing speed of schema matching was increased by 13 to 1800 times by reducing the checking process of the correlations. Second, the authors developed a heuristic solution for selecting the optimal weight factors used in the matching process to maintain a high accuracy by introducing a decision tree. The decision tree model was built using the content elements stored in the SCD, design companies, bridge types, and weight factors as input variables, and the matching accuracy as the target variable. The inverse-calculation method was applied to extract the weight factors from the decision tree model for high-accuracy schema matching results.

关键词： structural calculation document     bridge structure     XML Schema matching     weight factor     data mining     decision tree model    

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Instantaneous deflection of light-weight concrete slabs

Behnam VAKHSHOURI, Shami NEJADI

《结构与土木工程前沿（英文）》 2017年 第11卷 第4期   页码 412-423 doi: 10.1007/s11709-017-0416-8

摘要： Construction loading before the age of 28 d can have the most significant effects on the slabs, especially for multi-story structures. The changing properties of the young concrete complicate the prediction of serviceability design requirements also. An experimental investigation is performed on four simply supported Light-Weight Concrete (LWC) one-way slabs subjected to immediate loading at 14 d. Effects of aggregate type, loading levels and cracking moment together with the influences of ultimate moment capacity and service moment on the instantaneous deflection of slabs are studied. Comparison of the obtained results with predictions of existing models in the literature shows considerable differences between the recorded and estimated instantaneous deflection of LWC slabs. Based on sensitivity analysis of the effective parameters, a new equation is proposed and verified to predict the instantaneous deflection of LWC slabs subjected to loading at the age of 14 d.

关键词： instantaneous deflection     light-weight concrete     expanded polystyrene     effective moment of inertia     cracking moment     moment capacity     service moment    

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Characterization of soil low-molecular-weight organic acids in the Karst rocky desertification region

Xiaoliang LI, Xiaomin CHEN, Xia LIU, Lianchuan ZHOU, Xinqiang YANG

《环境科学与工程前沿（英文）》 2012年 第6卷 第2期   页码 195-203 doi: 10.1007/s11783-012-0391-1

摘要： Soil low-molecular-weight (LMW) organic acids play important roles in the soil-forming process and the cycling of nutrients in Karst regions. In this study, we quantified the contents of LMW organic acids (including lactate, acetate, formate, malate, and oxalate) in soil solution over the Karst region of Guizhou Province, China using ion chromatography. The concentration of total LMW organic acids in topsoil solution ranged from 0.358 to 1.823 μmol·g , with an average of 0.912 μmol·g . The mean concentrations of lactate, acetate, formate, malate, and oxalate were 0.212±0.089, 0.302±0.228, 0.301±0.214, 0.014±0.018 and 0.086±0.118 μmol·g , respectively. There were also significant difference in the contents of these acids among four phases of rocky desertification, and their concentrations decreased with the aggravation of rocky desertification. The concentrations of the LMW organic acids were significantly positive correlated each other. Significant positive correlations were also observed among individual LMW organic acids in soil solution, and between them and soil available P, available K, exchangeable Ca, respectively. Furthermore, the concentrations of LMW organic acids were significantly positively correlated with inorganic anions (chlorides, nitrates, and sulfates) in Karst topsoil solution. Therefore, the concentrations of soil LMW organic acids might be one of driving force in the Karst rock desertification process in Guizhou Province.

关键词： Karst rocky desertification     low-molecular-weight (LMW) organic acids     distribution characteristics     soil    

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Prediction of falling weight deflectometer parameters using hybrid model of genetic algorithm and adaptive

《结构与土木工程前沿（英文）》   页码 812-826 doi: 10.1007/s11709-023-0940-7

摘要： A falling weight deflectometer is a testing device used in civil engineering to measure and evaluate the physical properties of pavements, such as the modulus of the subgrade reaction (Y1) and the elastic modulus of the slab (Y2), which are crucial for assessing the structural strength of pavements. In this study, we developed a novel hybrid artificial intelligence model, i.e., a genetic algorithm (GA)-optimized adaptive neuro-fuzzy inference system (ANFIS-GA), to predict Y1 and Y2 based on easily determined 13 parameters of rigid pavements. The performance of the novel ANFIS-GA model was compared to that of other benchmark models, namely logistic regression (LR) and radial basis function regression (RBFR) algorithms. These models were validated using standard statistical measures, namely, the coefficient of correlation (R), mean absolute error (MAE), and root mean square error (RMSE). The results indicated that the ANFIS-GA model was the best at predicting Y1 (R = 0.945) and Y2 (R = 0.887) compared to the LR and RBFR models. Therefore, the ANFIS-GA model can be used to accurately predict Y1 and Y2 based on easily measured parameters for the appropriate and rapid assessment of the quality and strength of pavements.

关键词： falling weight deflectometer     modulus of subgrade reaction     elastic modulus     metaheuristic algorithms    

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Uncovering the effect of poly(ethylene-co-vinyl alcohol) molecular weight and vinyl alcohol content on

《化学科学与工程前沿（英文）》 2023年 第17卷 第10期   页码 1484-1502 doi: 10.1007/s11705-023-2331-y

摘要： Various hydrophilic poly(ethylene-co-vinyl alcohol) (EVOH) were used herein to precisely control the structure and hydrodynamic properties of polysulfone (PSF) membranes. Particularly, to prepare pristine PSF and PSF/EVOH blends with increasing vinyl alcohol (VOH: 73%, 68%, 56%), the non-solvent-induced phase separation (NIPS) technique was used. Polyethylene glycol was used as a compatibilizer and as a porogen in N,N-dimethylacetamide. Rheological and ultrasonic separation kinetic measurements were also carried out to develop an ultrafiltration membrane mechanism. The extracted membrane properties and filtration capabilities were systematically compared to the proposed mechanism. Accordingly, the addition of EVOH led to an increase in the rheology of the dopes. The resulting membranes exhibited a microporous structure, while the finger-like structures became more evident with increasing VOH content. The PSF/EVOH behavior was changed from immediate to delayed segregation due to a change in the hydrodynamic kinetics. Interestingly, the PSF/EVOH32 membranes showed high hydrophilicity and achieved a pure water permeability of 264 L·m–2·h–1·bar–1, which was higher than that of pure PSF membranes (171 L·m–2·h–1·bar–1). In addition, PSF/EVOH32 rejected bovine serum albumin at a high rate (> 90%) and achieved a significant restoration of permeability. Finally, from the thermodynamic and hydrodynamic results, valuable insights into the selection of hydrophilic copolymers were provided to tailor the membrane structure while improving both the permeability and antifouling performance.

关键词： polysulfone     blend modification     ultrafiltration membrane     formation hydrodynamics     poly(ethylene-co-vinyl alcohol) copolymer    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized

《医学前沿（英文）》 2021年 第15卷 第3期   页码 460-471 doi: 10.1007/s11684-021-0861-6

摘要： Lifestyle interventions, including dietary adjustments and exercise, are important for obesity management. This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet (LCD) or exercise is more effective in metabolism improvement. Forty-five eligible subjects were randomly divided into an LCD group (n=22) and an exercise group (EX, n=23). The subjects either adopted LCD (carbohydrate intake<50 g/day) or performed moderate-to-vigorous exercise (≥30 min/day) for 3 weeks. After the interventions, LCD led to a larger weight loss than EX (−3.56±0.37 kg vs. −1.24±0.39 kg, P<0.001), as well as a larger reduction in fat mass (−2.10±0.18 kg vs. −1.25±0.24 kg, P=0.007) and waist circumference (−5.25±0.52 cm vs. −3.45±0.38 cm, P=0.008). Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance. Triglycerides decreased in both two groups, whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group. Various glycemic parameters, including serum glycated albumin, mean sensor glucose, coefficient of variability (CV), and largest amplitude of glycemic excursions, substantially declined in the LCD group. Only CV slightly decreased after exercise. This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance. Compared with exercise, LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

关键词： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean sensor glucose    

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Computation model for corrosion resistance of nanocrystalline zircaloy-4

ZHANG Xiyan, ZHU Yutao, LIU Qing, LUAN Baifeng, HUANG Guangjie, LI Cong, ZHANG Xiyan, SHI Minghua, LIU Nianfu, ZHANG Xiyan, LI Cong

《能源前沿（英文）》 2008年 第2卷 第4期   页码 386-389 doi: 10.1007/s11708-008-0102-6

摘要： A computation model of the corrosion rate versus grain size of nanocrystalline zircaloy-4 was presented. The influence of the second phase on the conductivity of alloy was considered. By this model, the corrosion rate of nanocrystalline zircaloy-4 at different temperature was calculated. The results show that the corrosion rate constant and weight gain of nanocrystalline zircaloy-4 decrease with the decrease of grain size, and that the corrosion weight gain of nanocrystalline zircaloy-4 is less than that of zircaloy-4 of coarse grain. The computational result is coincident with the experimental result.

关键词： corrosion     constant     corrosion weight     weight     influence    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 376-380 doi: 10.1007/s11684-012-0228-0

摘要：

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

关键词： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

《结构与土木工程前沿（英文）》 2022年 第16卷 第7期   页码 871-881 doi: 10.1007/s11709-022-0863-8

摘要： The failure criteria of practical soil mass are very complex, and have significant influence on the safety factor of slope stability. The Coulomb strength criterion and the power-law failure criterion are classically simplified. Each one has limited applicability owing to the noticeable difference between calculated predictions and actual results in some cases. In the work reported here, an analysis method based on the least square support vector machine (LSSVM), a machine learning model, is purposefully provided to establish a complex nonlinear failure criterion via iteration computation based on strength test data of the soil, which is of more extensive applicability to many problems of slope stability. In particular, three evaluation indexes including coefficient of determination, mean absolute percentage error, and mean square error indicate that fitting precision of the machine learning-based failure criterion is better than those of the linear Coulomb criterion and nonlinear power-law criterion. Based on the proposed LSSVM approach to determine the failure criterion, the limit equilibrium method can be used to calculate the safety factor of three-dimensional slope stability. Analysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum relative errors between the proposed approach and the linear failure criterion-based method and the power-law failure criterion-based method are about 12% and 7%, respectively.

关键词： slope stability     safety factor     failure criterion     least square support vector machine    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

《医学前沿（英文）》 2023年 第17卷 第2期   页码 317-329 doi: 10.1007/s11684-022-0931-4

摘要： Long noncoding RNAs (lncRNAs) play a critical role in the regulation of atherosclerosis. Here, we investigated the role of the lncRNA growth arrest-specific 5 (lncR-GAS5) in atherogenesis. We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis, which presented as increased plaque size and reduced collagen content. Moreover, impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells. By contrast, lncR-GAS5 knockdown promoted autophagy. Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3I ratio and decreased the P62 level, thus enhancing the formation of autophagic vacuoles, autolysosomes, and autophagosomes. Mechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium, which was reversed by the knockdown of SRSF10. Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene, SRSF10. Notably, miR-193-5p overexpression decreased plaque size and increased collagen content. Altogether, these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy. In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway. Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

关键词： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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Investigation on a cylindrical ultrasonic micromotor

ZHU Hua, CHEN Chao, ZHAO Chunsheng

《机械工程前沿（英文）》 2007年 第2卷 第4期   页码 394-398 doi: 10.1007/s11465-007-0068-9

摘要： The relationship between the arrangement of ceramics and the force coefficient shows that the maximum excitation efficiency will be obtained when the ceramics are placed at the trough of the first bending mode of the stator. Therefore, a cylindrical ultrasonic micromotor with a novel stator is proposed. The prototype motor is 5 mm in diameter, 30 mm in length and 4.2 g in weight. The micromotor operates with the first bending mode at 53 kHz. Its maximum speed is 350 r/min when the drive voltage is 200 V and the stall torque reaches 2.5 mN · m. As this motor is suitable for miniaturization because of its simple structure, another cylindrical ultrasonic micromotor is developed. Piezoelectric ceramic tube is used as its stator. This micromtor is 2 mm in diameter, 7 mm in length and 0.258 g in weight. Its speed reaches 813 r/min when the drive voltage is 60 V at 75 kHz. The operation mechanism, structure and design method of these two motors are introduced.

关键词： coefficient     bending     kHz     suitable     weight    

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The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

《环境科学与工程前沿（英文）》 2015年 第9卷 第6期   页码 1015-1024 doi: 10.1007/s11783-014-0670-0

摘要： The Ecological Footprint (EF), a physical indicator to measure the extent of humanity’s use of natural resources, has gained much attention since it was first used by Wackernagel and Rees in 1996. In order to appraise land area types with different levels of productivity, they introduced the concept of an equivalence factor. This relates to the average primary biomass productivities of different types of land (i.e. arable land, pasture, forest, water/fishery, built-up land and fossil energy land) to the regional average primary biomass productivity of all land types in a given year. Hence, the equivalence factor is an important parameter in the EF model and it directly affects the reliability of all results. Thus, this article calculates equivalence factors on the national and provincial levels in China based on Net Primary Production (NPP) from MODIS 1 km data in 2008. Firstly, based on the Light Utility Efficiency and CASA model, the NPP of different biologically productive lands of China and of different provinces was calculated. Secondly, China’s equivalence factor for 6 land area types was calculated based on NPP: arable land and built-up land has an equivalence factor of 1.71, forest and fossil energy land has a factor of 1.41, pasture has a factor of 0.44 and water/fishery 0.35; Finally, the equivalence factor of 6 land area types in different provinces was also calculated. The NPP of each ecosystem type varies along with the equivalence factor in different provinces. However, the ranking of the equivalence factors in different provinces remain the same, with that of arable land being the largest, and the water/fishery being the smallest.

关键词： ecological footprint     equivalence factor     net primary production     biological capacity     land types    

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Effects of molecular weight and concentration of carboxymethyl cellulose on morphology of hydroxyapatite

Ruiqiang LIU,Rattan LAL

《环境科学与工程前沿（英文）》 2015年 第9卷 第5期   页码 804-812 doi: 10.1007/s11783-015-0785-y

摘要： Nano-sized apatite particles (nAP) synthesized with carboxymethyl cellulose (CMC) have shown great application potentials in in situ heavy metal remediation. However, differences in CMC’s properties effects on the size of nAP produced are not well understood. In this paper, two types of CMC, with respective molecular weights (MW) of ~120000 and ~240000 Dalton or respective polymerization degrees of 500 (CMC-500) and 1050 (CMC-1050), were studied in a concentration range of 0.05%–0.5% (w/w) for nAP synthesis. Morphology of the particles was characterized with transmission electron microscopy (TEM). Results showed that 0.05% CMC-500 solution gave an average particle size of 148.7±134.9 nm, 0.25% CMC-500 solution produced particles of 21.8±20.4 nm, and, 0.5% CMC-500 solution contained particles of 15.8±7.7 nm. In comparison, 0.05% CMC-1050 solution produced nanoparticles of 6.8±3.2 nm, 0.25% CMC-1050 produced smaller nAP of 4.3±3.2 nm, and 0.5% CMC-1050 synthesized the smallest nanoparticles in this study, with an average diameter of 3.0±2.1 nm. Chemical composition of the products was identified with X-ray diffraction (XRD) as pure hydroxyapatite. Interactions between nAP and CMC were discussed with help of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic data. This study showed that CMC at higher concentration as well as higher MW facilitated to produce finer nanoparticles, showing that nAP size could be manipulated by selecting appropriate CMC MW and/or applying appropriate CMC concentration.

关键词： nanotechnology     nanoparticles     apatite     carboxymethyl cellulose (CMC)     particle size    

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标题 作者 时间 类型 操作

Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICU

期刊论文

Solving topology optimization problems by the Guide-Weight method

Xinjun LIU, Zhidong LI, Liping WANG, Jinsong WANG

期刊论文

Heuristic solution using decision tree model for enhanced XML schema matching of bridge structural calculation documents

Sang I. PARK, Sang-Ho LEE

期刊论文

Instantaneous deflection of light-weight concrete slabs

Behnam VAKHSHOURI, Shami NEJADI

期刊论文

Characterization of soil low-molecular-weight organic acids in the Karst rocky desertification region

Xiaoliang LI, Xiaomin CHEN, Xia LIU, Lianchuan ZHOU, Xinqiang YANG

期刊论文

Prediction of falling weight deflectometer parameters using hybrid model of genetic algorithm and adaptive

期刊论文

Uncovering the effect of poly(ethylene-co-vinyl alcohol) molecular weight and vinyl alcohol content on

期刊论文

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized

期刊论文

Computation model for corrosion resistance of nanocrystalline zircaloy-4

ZHANG Xiyan, ZHU Yutao, LIU Qing, LUAN Baifeng, HUANG Guangjie, LI Cong, ZHANG Xiyan, SHI Minghua, LIU Nianfu, ZHANG Xiyan, LI Cong

期刊论文

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

null

期刊论文

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

期刊论文

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

期刊论文

Investigation on a cylindrical ultrasonic micromotor

ZHU Hua, CHEN Chao, ZHAO Chunsheng

期刊论文

The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

期刊论文

Effects of molecular weight and concentration of carboxymethyl cellulose on morphology of hydroxyapatite

Ruiqiang LIU,Rattan LAL

期刊论文